Malaria in Al-Andalus: from written medical sources to a proposal for paleoparasitological study
DOI:
https://doi.org/10.17561/aytm.v33.9698Keywords:
Malaria, Paludism, Written sources, Paleoparasitology, Al-AndalusAbstract
Malaria, also known as paludism, is a parasitic disease caused by protozoa of the genus Plasmodium and transmitted by the female Anopheles mosquito. It is notable for its high morbimortality and its importance throughout human history.
References to this parasitosis can be traced in contemporary sources, especially in ancient medical texts. In Al-Andalus, where medical knowledge became influenced by Greco-Latin and Oriental writings, descriptions of symptoms indicate the presence of malaria in populations of the Iberian Peninsula.
This study reviews possible evidence of malaria in medical texts from Al-Andalus and presents a novel proposal for paleoparasitological studies in areas especially susceptible to the presence of these parasites in this culture.
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ACHARYA, Pragyan; MANIKA GARG, Praveen K.; MUNJAL, Akshay; RAJA, Ravadev (2017): “Host–parasite interactions in human malaria: clinical implications of basic research”, Frontiers in Microbiology, 8, p. 889. https://doi.org/10.3389/fmicb.2017.00889
ALBEROLA-ROMÁ, Armando; BERNABÉ GIL, David (1999): “Tercianas y calenturas en tierras meridionales valencianas: una aproximación a la realidad médica y social del siglo XVIII”, Revista de Historia Moderna, 17, pp. 95-112. https://doi.org/10.14198/RHM1998-1999.17.06
AL-KHAFIF, Ghada Darwish; ROKIA EL-BANNA, Nancy Khattab; TAMER GAD, Rashed; SALWA, Dahesh (2018): “The Immunodetection of Non-Falciparum Malaria in Ancient Egyptian Bones (Giza Necropolis)”, BioMed Research International, 2018. https://doi.org/10.1155/2018/9058108
ÁLVAREZ DE MORALES, Camilo (1999): “El hombre ante la enfermedad”, in C. Álvarez de Morales and E. Molina López (Eds.), La Medicina en al-Andalus, pp. 69-89. Granada: Junta de Andalucía y Fundación El legado andalusí.
ÁLVAREZ DE MORALES, Camilo (2006): “Elementos mágicos y religiosos en la medicina andalusí”, ‘ILU. Revista de Ciencias de las Religiones. Anejos, 16, pp. 23–46.
ÁLVAREZ DE MORALES, Camilo; MOLINA LÓPEZ, Emilio (1999): “El patrimonio científico de al-Ándalus. Su elaboración y transmisión”, in C. Álvarez de Morales and E. Molina López (Eds.), La Medicina en al-Andalus, pp. 13-29. Granada: Junta de Andalucía y Fundación El legado andalusí.
ASENSO-OKYERE, Kwadwo; ASANTE, Félix A.; TAREKEGN, Jifar; ANDAM, Kwaw S. (Eds.) (2009): The Linkages between Agriculture and Malaria: Issues for Policy, Research, and Capacity Strengthening. Washington: International Food Policy Research Institute.
BAKER, David A. (2010): “Malaria gametocytogenesis”, Molecular and Biochemical Parasitology. 172(2), pp. 57–65. https://doi.org/10.1016/j.molbiopara.2010.03.019
BECK-JOHNSON, Lindsay M.; NELSON, William A.; PAAIJMANS, Krij; READ, Andrew; THOMAS, Matthew B.; BJØRNSTAD, Ottar (2013): “The Effect of Temperature on Anopheles Mosquito Population Dynamics and the Potential for Malaria Transmission”, PLOS One, 8(11), e79276. https://doi.org/10.1371/journal.pone.0079276
BEESON, James G.; BROWN, Graham V. (2002): “Pathogenesis of Plasmodium Falciparum malaria: the roles of parasite adhesion and antigenic variation”, Cellular and Molecular Life Sciences CMLS, 59, pp. 258–271. https://doi.org/10.1007/s00018-002-8421-y
BIANUCCI, Raffaella; ADAUTO, Araujo; PUSCH, Carsten M.; NERLICH, Andreas G. (2015): “The Identification of Malaria in Paleopathology—An In-Depth Assessment of the Strategies to Detect Malaria in Ancient Remains”, Acta Tropica, 152, pp. 176–180. https://doi.org/10.1016/j.actatropica.2015.09.002
BIANUCCI, Raffaella; MATTUTINO, Grazia; LALLO, Rudy; CHARLIER, Philippe; JOUIN-SPRIET, Hélène; PELUSO, Alberto; HIGHAM, Thomas; TORRE, Carlo; RABINO MASSA, Emma (2008): “Immunological evidence of Plasmodium falciparum infection in an Egyptian child mummy from the Early Dynastic Period”, Journal of Archaeological Science, 35(7), pp. 1880-1885. https://doi.org/10.1016/J.JAS.2007.11.019
BIANUCCI, Raffaella; TOGNOTTI, Eugenia; GIUFFRA, Valentina; FORNACIARI, Gino; MONTELLA, Andrea; MILANESE, Marco; FLORIS, Roberta; BANDIERA, Pasquale (2014): “Origins of malaria and leishmaniasis in Sardinia: first results of paleoimmunological study”, Pathologica, 106, p. 90.
BOUALAM, Mahmoud A.; PRADINES, Bruno; DRANCOURT, Michel; BARBIERI, Rémi (2021): “Malaria in Europe: a historical perspective”, Frontiers in Medicine, 8, 691095. https://doi.org/10.3389/fmed.2021.691095
BRICKLEY, Megan B. (2018): “Cribra orbitalia and porotic hyperostosis: A biological approach to diagnosis”, American Journal of Physical Anthropology, 167(4), pp. 896-902. https://doi.org/10.1002/ajpa.23701
BRYAN, Cyril P.; SMITH, Elliot G. (1930): Ancient Egyptian Medicine: The Papyrus Ebers. Chicago: Ares Publishers Chicago.
BUENO MARÍ, Rubén; JIMÉNEZ PEYDRÓ, Ricardo (2010): “Crónicas de arroz, mosquitos y paludismo en España: el caso de la provincia de Valencia (ss. XVIII-XX)”, Hispania, 70(236), pp. 687–708. https://doi.org/10.3989/hispania.2010.v70.i236.329
BUENO VERGARA, Eduardo (2017): “Fiebres tercianas, sequías y lluvias torrenciales en el Alicante del Setecientos”, Revista de Historia Moderna, 35, pp. 377-409. https://doi.org/10.14198/RHM2017.35.11
CARTER, Richard; MENDIS, Kamini N. (2002): “Evolutionary and historical aspects of the burden of malaria”, Clinical Microbiology Reviews, 15(4), pp. 564–594. https://doi.org/10.1128/CMR.15.4.564-594.2002
CASTILLA BRAZALES, Juan (1999): “Noticias médicas en fuentes árabes sobre al-Ándalus”, in C. Álvarez de Morales and E. Molina López (Eds.), La Medicina en al-Andalus, pp. 29-69. Granada: Junta de Andalucía and Fundación El legado andalusí.
CHANDIO, Abdul R. (2021): “The House of Wisdom (Bait Al-Hikmah): A Sign of Glorious Period of Abbasids Caliphate and Development of Science”, International Journal of Engineering and Information Systems IJEAIS, 5(3), pp. 1-6.
CHAVES, Luis F.; TALEO, George; KALKOA, Morris; KANEKO, Akira (2011): “Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settings”, Transactions of the Royal Society of Tropical Medicine and Hygiene, 105(4), pp. 226-231. https://doi.org/10.1016/j.trstmh.2011.01.001
COPPOLA-BOVE, Lorenza; KIRKPATRICK, Casey L.; VIGIL-ESCALERA, Alfonso; BOTELLA-LÓPEZ, Miguel C.; BOS, Kirsten I. (2024): “A morphological and molecular approach to investigating infectious disease in early medieval Iberia: The necropolis of La Olmeda (Palencia, Spain)”, American Journal of Biological Anthropology, 185, e24994. https://doi.org/10.1002/ajpa.24994
CORDERO DEL CAMPILLO, Miguel (1980): Panorama de la Parasitología Española. Madrid: Laboratorios Sobrino.
COWMAN, Alan F.; CRABB, Brendan S. (2006): “Invasion of red blood cells by malaria parasites”, Cell, 124(4), pp. 755–766. https://doi.org/10.1016/j.cell.2006.02.006
COX, Francis E. G. (2002): “History of human parasitology”, Clinical Microbiology Reviews, 15(4), pp. 595–612. https://doi.org/10.1128/CMR.15.4.595-612.2002
COX, Francis E. G. (2010): “History of the discovery of the malaria parasites and their vectors”, Parasites & Vectors, 3(1), pp. 1–9. https://doi.org/10.1186/1756-3305-3-5
DE LA PUENTE, Cristina (2014): Médicos de al-Ándalus perfumes, ungüentos y jarabes. Madrid: Nivola.
DEL PORTILLO, Hernando A.; FERRER, Mireia; BRUGAT, Thibaut; MARTIN-JAULAR, Lorena; LANGHORNE, Jean; LACERDA, Marcus V. (2012): “The role of the spleen in malaria”, Cellular Microbiology, 14(3), pp. 343-355. https://doi.org/10.1111/j.1462-5822.2011.01741.x
DEL PRADO, Gema; HERNÁN GARCÍA, Cristina; MORENO CEA, Lourdes; FERNÁNDEZ ESPINILLA, Virginia; MUÑOZ MORENO, María; DELGADO MÁRQUEZ, Antonio; POLO POLO, María; ANDRÉS GARCÍA, Irene (2014): “Malaria in developing countries”, The Journal of Infection in Developing Countries, 8(1), pp. 1–4. https://doi.org/10.3855/jidc.4610
DEMISSEW, Assalif; HAWARIA, Dawit; KIBRET, Solomon; ANIMUT, Adebe; TSEGAYE, Arega; LEE, Ming C.; YAN, Guiyun; YEWHALAW, Delenasaw (2020): “Impact of sugarcane irrigation on malaria vector Anopheles mosquito fauna, abundance and seasonality in Arjo-Didessa, Ethiopia”, Malaria Journal, 19(1), pp. 1-8. https://doi.org/10.1186/s12936-020-03416-0
DILLON, Andrew; FRIEDMAN, Jed; SERNEELS, Pieter M. (2014): “Health Information, Treatment, and Worker Productivity: Experimental Evidence from Malaria Testing and Treatment among Nigerian Sugarcane Cutters”, World Bank Policy Research Working Paper, 7120, pp. 1-46.
DUFOUR, Benjamin; LE BAILLY, Matthieu (2013): “Testing new parasite egg extraction methods in paleoparasitology and an attempt at quantification”, International Journal of Paleopathology, 3(3), pp. 199–203. https://doi.org/10.1016/j.ijpp.2013.03.008
ENGWERDA, Christian R.; BEATTIE, Lynette; AMANTE, Fiona H. (2005): “The importance of the spleen in malaria”, Trends in Parasitology, 21(2), pp. 75-80. https://doi.org/10.1016/j.pt.2004.11.008
FERNÁNDEZ ASTASIO, Balbina (2018): La Erradicación Del Paludismo En España: Aspectos Biológicos de La Lucha Antipalúdica. Doctoral dissertation. Universidad Complutense de Madrid, Madrid.
FERREIRA, Luiz F.; REINHARD, Karl J.; ARAÚJO, A. (2014): Foundations of Paleoparasitology. Río de Janeiro: Editora Fiocruz. https://doi.org/10.7476/9788575415986
FORNACIARI, Gino; GIUFFRA, Valentina; FERROGLIO, Ezio; BIANUCCI, Raffaella (2010a): “Malaria was “the killer” of Francesco I de’ Medici (1531-1587)”, The American Journal of Medicine, 123, pp. 568-569. https://doi.org/10.1016/J.AMJMED.2009.12.020
FORNACIARI, Gino; GIUFFRA, Valentina; FERROGLIO, Ezio; GINO, Sarah; BIANUCCI, Raffaella (2010b): “Plasmodium falciparum immunodetection in bone remains of members of the Renaissance Medici family (Florence, Italy, sixteenth century)”, Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(9), pp. 583-587. https://doi.org/10.1016/J.TRSTMH.2010.06.007
GELABERT, Pere; SANDOVAL-VELASCO, Marcela; OLALDE, Iñigo; FREGEL, Rosa; RIEUX, Adrien; ESCOSA, Raül; ARANDA, Carles; PAAIJMANS, Krijn; MUELLER, Ivo; GILBERT, Thomas; LALUEZA-FOX, Carles (2016): “Mitochondrial DNA from the eradicated European Plasmodium vivax and P. falciparum from 70-year-old slides from the Ebro Delta in Spain”, Proceedings of the National Academy of Sciences of the United States of America, 113(41), pp. 11495-11500. https://doi.org/10.1073/pnas.1611017113
GOWLAND, Rebecca L.; WESTERN, Gaynor A. (2012): “Morbidity in the marshes: Using spatial epidemiology to investigate skeletal evidence for malaria in Anglo‐Saxon England (AD 410–1050)”, American Journal of Physical Anthropology, 147(2), pp. 301-311. https://doi.org/10.1002/ajpa.21648
GUTIÉRREZ AROCA, Juan B. (2018): “Desarrollo de la ciencia y la medicina en Al-Andalus”, Arte, Arqueología e Historia, 25, pp. 133-148.
HAWASS, Zahi; GAD, Yehia Z.; SOMAIA, Ismail; KHAIRAT, Rabab; FATHALLA, Dina; HASAN, Naglaa; AHMED, Amal; ELLEITHY, Hisham; BALL, Markus; GABALLAH, Fawzi (2010): “Ancestry and Pathology in King Tutankhamun’s Family”, Jama, 303(7), pp. 638-647. https://doi.org/10.1001/jama.2010.121
HEDRICK, Philip W. (2011): “Population genetics of malaria resistance in humans”, Heredity, 107(4), pp. 283–304. https://doi.org/10.1038/hdy.2011.16
HEDRICK, Philip W. (2012): “Resistance to malaria in humans: the impact of strong, recent selection”, Malaria Journal, 11(1), pp. 1–7. https://doi.org/10.1186/1475-2875-11-349
HERRERA CARRANZA, M. (2021): “A propósito de pandemias: Ibn Jatima de Almería anticipa el concepto fisiopatológico de fallo multiorgánico en el siglo XIV”, Medicina Intensiva, 45(6), pp. 362-370. https://doi.org/10.1016/j.medin.2020.05.010.
HOEPPLI, Reinhard (1956): “The knowledge of parasites and parasitic infections from ancient times to the 17th century”, Experimental Parasitology, 5(4), pp. 398–419. https://doi.org/10.1016/0014-4894(56)90024-8
IBN AL-JATIB, Muhammad (1977): Mi‘yar al-ijtiyâr fi dikr al ma‘âhid wa-l-diyâr. Marruecos: Instituto Universitario de Investigación Científica.
IJUMBA, Jasper N.; MOSHA, Franklin W.; LINDSAY, Steve W. (2002): “Malaria transmission risk variations derived from different agricultural practices in an irrigated area of northern Tanzania”, Medical and Veterinary Entomology, 16(1), pp. 28-38. https://doi.org/10.1046/j.0269-283x.2002.00337.x
JIMÉNEZ‐BROBEIL, Sylvia A.; MAROTO, Rosa M.; MILELLA, Marco; LAFFRANCHI, Zita; REYES BOTELLA, Candela (2022): “Introduction of sugarcane in Al‐Andalus (Medieval Spain) and its impact on children’s dental health”, International Journal of Osteoarchaeology, 32(1), pp. 283-293. https://doi.org/10.1002/oa.3064
KNORR, Delaney A.; SMITH, William P. W.; LEDGER, Marissa L.; PEÑA-CHOCARRO, Leonor; PÉREZ-JORDÁ, Guillem; CLAPÉS, Rafael; PALMA, María; MITCHELL, Piers (2019): “Intestinal parasites in six Islamic medieval period latrines from 10th-11th century Córdoba (Spain) and 12th-13th century Mértola”, International Journal of Paleopathology, 26, pp. 75-83. https://doi.org/10.1016/j.ijpp.2019.06.004
LALREMRUATA, Albert; BALL, Markus; BIANUCCI, Raffaella; WELTE, Beatrix; NERLICH, Andreas; KUN, Jürgen; PUSCH, Carsten (2013): “Molecular Identification of Falciparum Malaria and Human Tuberculosis Co-Infections in Mummies from the Fayum Depression (Lower Egypt)”, PlOS One, 8(4), e60307. https://doi.org/10.1371/journal.pone.0060307
LE BAILLY, Matthieu; MAICHER, Céline; ROCHE, Kévin; DUFOUR, Benjamin (2021): “Accessing Ancient Population Lifeways through the Study of Gastrointestinal Parasites: Paleoparasitology”, Applied Sciences, 11(11), 4868. https://doi.org/10.3390/app11114868
LÓPEZ-GIJÓN, Ramón; CAMARÓS, Edgard; RUBIO-SALVADOR, Ángel; DURAS, Salvatore; BOTELLA-LÓPEZ, Miguel C.; ALEMÁN-AGUILERA, Inmaculada; RODRÍGUEZ-AGUILERA, Ángel; BUSTAMANTE-ÁLVAREZ, Macarena; SÁNCHEZ-BARBA, Lydia P.; DUFOUR, Benjamin; LE BAILLY, Matthieu (2023b): “Implications of the prevalence of Ascaris sp. in the funerary context of a Late Antique population (5th-7th c.) in Granada (Spain)”, International Journal of Paleopathology, 43, pp. 45-50. https://doi.org/10.106/j.ijpp.2023.09.002
LÓPEZ-GIJÓN, Ramón; CARNICERO, Silvia; BOTELLA-LÓPEZ, Miguel; CAMARÓS, Edgard (2023a): “Zoonotic parasite infection from a funerary context: A Late Antique child case from Cantabrian Spain”, International Journal of Paleopathology, 41, pp. 55-58. https://doi.org/10.1016/j.ijpp.2023.03.003
LÓPEZ-GIJÓN, Ramón; DUFOUR, Benjamin; COPPOLA-BOVE, Lorenza; MARTÍN-ALONSO, José F.; BOTELLA LÓPEZ, Miguel C.; LE BAILLY, Matthieu (2021): “Los inicios de la Paleoparasitología como disciplina científica y su aportación a la Antropología Física”, Revista Española de Antropología Física, 44, pp. 41–46.
LÓPEZ-GIJÓN, Ramón; JIMÉNEZ-BROBEIL, Sylvia; MAROTO-BENAVIDES, Rosa; DURAS, Salvatore; SULIMAN, Amjad; FERNÁNDEZ-ROMERO, Pablo; BOTELLA-LÓPEZ, Miguel; SÁNCHEZ-MONTES, Francisco; MITCHELL, Piers D. (2024): “Parasite eggs in 16th-18th century cesspits from Granada (Spain)”, Journal of Archaeological Science: Reports, 53, 104342. https://doi.org/10.1016/j.jasrep.2023.104342
LÓPEZ ROMÁN, Ramón (1990): Pasado y presente del paludismo. La Laguna: Universidad de la Laguna.
LOUFOUMA-MBOUAKA, Alvie; BINDER, Michaela; NOEDL, Harald; GAMBLE, Michelle (2020): “Evaluation of rapid diagnostic tests and Enzyme Linked Immunoassay in the detection of malaria in ancient human remains”, Journal of Archaeological Science, 116, 105118. https://doi.org/10.1016/J.JAS.2020.105118
LOUFOUMA-MBOUAKA, Alvie; GAMBLE, Michelle; WURST, Christina; JÄGER, Heidi Y.; MAIXNER, Frank; ZINK, Albert; NOEDL, Harald; BINDER, Michaela (2021): “The elusive parasite: comparing macroscopic, immunological, and genomic approaches to identifying malaria in human skeletal remains from Sayala, Egypt (third to sixth centuries AD)”, Archaeological and Anthropological Sciences, 13(7), pp. 1–22. https://doi.org/10.1007/s12520-021-01350-z
MACHADO SANTIAGO, Rafael; JIMÉNEZ BAUTISTA, Francisco (1995): “Proceso de transformación del paisaje agrario del litoral granadino (vega de Motril-Salobreña): Implantación, desarrollo y crisis de la caña de azúcar: Conflictos y tendencias”, Cuadernos geográficos de la Universidad de Granada, 24, pp. 123–38.
MAICHER, Céline; HOFFMANN, Alizé; CÔTÉ, Nathalie; PALOMO PÉREZ, Antoni; SAÑA SEGUÍ, María; LE BAILLY, Matthieu (2017): “Paleoparasitological investigations on the Neolithic lakeside settlement of La Draga (Lake Banyoles, Spain)”, The Holocene, 27(11), pp. 1659-1668. https://doi.org/10.1177/0959683617702236
MALPICA CUELLO, Antonio (2012): “La caña de azúcar en los agroecosistemas irrigados andalusíes”, in A. Viña Segura and D. Corbella Díaz (Eds.), La ruta azucarera atlántica: Historia y documentación, pp. 9-21. Portugal: Centro de Estudios de História do Atlántico.
MARCINIAK, Stephanie; PROWSE, Tracy L.; HERRING, Ann; KLUNK, Jennifer; KUCH, Melanie; DUGGAN, Ana T.; BONDIOLI, Luca; HOLMES, Edward C.; POINAR, Hendrik (2016): “Plasmodium falciparum malaria in 1st–2nd century CE southern Italy”, Current Biology, 26(23), pp. 1220-1222. https://doi.org/10.1016/j.cub.2016.10.016
MICHEL, Megan; SKOURTANIOTI, Eirini; PIERINI, Federica; GUEVARA, Evelyn K.; MÖTSCH, Angela; KOCHER, Arthur; BARQUERA, Rodrigo; BIANCO, Raffaela A.; CARLHOFF, Selina; COPPOLA BOVE, Lorenza; FREILICH, Suzzane; GIFFIN, Karen; HERMES, Taylor; HIß, Alina; KNOLLE, Florian; NELSON, Elizabeth A.; NEUMANN, Gunnar U.; PAPAC, Luka; PENSKE, Sandra et alii. (2024): “Ancient Plasmodium genomes shed light on the history of human malaria”, Nature, 631(8019), pp. 125–133. https://doi.org/10.1038/s41586-024-07546-2
MILLER, Ron L.; IKRAM, Salima; ARMELAGOS, George J.; WALKER, Ross; HARER, Benson; SHIFF, Charles; BAGGETT, D., CARRIGAN, M.; MARET, S.M. (1994): “Diagnosis of Plasmodium falciparum infections in mummies using the rapid manual Para Sight™-F Test”, Transactions of the Royal Society of Tropical Medicine and Hygiene, 88(1), pp. 31-32. https://doi.org/10.1016/0035-9203(94)90484-7
MITCHELL, Piers D. (2017): “Improving the use of historical written sources in paleopathology”, International Journal of Paleopathology, 19, pp. 88-95. https://doi.org/10.1016/j.ijpp.2016.02.005
MOLINA-PRADOS, Laura (2017): El Paludismo En España Desde Una Perspectiva Histórica. Bachelor´s final project. Universidad Complutense de Madrid, Madrid.
MURO, María (2017): El paisaje cultural del azúcar en la Vega del Guadalfeo en época preindustrial (siglos X-XVIII). Doctoral dissertation. Universidad de Granada, Granada.
NERLICH, Andreas (2016): “Paleopathology and Paleomicrobiology of Malaria”, Microbiology Spectrum, 4(6), 4.6.02. https://doi.org/10.1128/microbiolspec.PoH-0006-2015
NERLICH, Andreas; SCHRAUT, Bettina; DITTRICH, Sabine; JELINEK, Thomas; ZINK, Albert (2008): “Plasmodium falciparum in ancient Egypt”, Emerging Infectious Diseases, 14(8), pp. 1317-1319. https://doi.org/10.3201/eid1408.080235
NEWFIELD, Timothy (2017): “Malaria and malaria-like disease in the early Middle Ages”, Early Medieval Europe, 25(3), pp. 251-300. https://doi.org/10.1111/emed.12212
O’DONNELL, Lexi; HILL, Ethan C.; ANDERSON, Amy; EDGAR, Heather (2020): “Cribra orbitalia and porotic hyperostosis are associated with respiratory infections in a contemporary mortality sample from New Mexico”, American Journal of Physical Anthropology, 173(4), pp. 721-733. https://doi.org/10.1002/ajpa.24131
PEÑA DÍAZ, Manuel (2012): Breve Historia de Andalucía. Sevilla: Junta de Andalucía, Centro de Estudios Andaluces and Consejería de la Presidencia e Igualdad.
PEÑA MUÑOZ, Carmen; GIRÓN IRUESTE, Fernando (2005): “The Identification of Medieval Fevers According to Al-Isra’ili, Avenzoar and Bernard Gordon”, Cronos, 8, pp. 95-120.
PEÑA MUÑOZ, Carmen; GIRÓN IRUESTE, Fernando (2010): “El “capítulo sobre la conservación de la salud” del Kitáb al-taysir fí l-mudawat wa-l-tadbir de Avenzoar (c. 1095-1162)”, Dynamis, 30, pp. 281–308. https://doi.org/10.4321/S0211-95362010000100012
PERDIGUERO GIL, Enrique (2005): “Huerta, Arroz y Mosquitos: La Lucha Contra El Paludismo En La Provincia de Alicante”, Cuadernos de Historia de España, 79, pp. 203–235.
RABINO MASSA, Emma; CERUTTI, Nicoletta; SAVOIA, A.; Marin, D. (2000): “Malaria in ancient Egypt: paleoimmunological investigations in predynastic mummified remains”, Chungará, 32(1), pp. 7-9. https://doi.org/10.4067/S0717-73562000000100003
RIERA MELIS, Antoni (2016): “De la cuenca Del Yangtsé a las marismas del Guadalquivir: la introducción del cultivo y del Consumo del Arroz asiático (Oryza Sativa) en Al-Andalus durante la Edad Media”, Estudis d’història agrària, 28, pp. 149–67. https://doi.org/10.1344/eha.2016.28.149-167
ROBERTS, Larry; JANOVY, John (2008): “Phylum Apicomplexa: Malaria Organisms and Piroplasms”, in L. Roberts and J. Janovy (Eds.), Foundations of Parasitology, pp. 147-174. New York: McGraw-Hill.
ROMERA BARBERA, Aida; HERTZEL, Darwin; REINHARD, Karl J. (2020): “Attempting to simplify methods in parasitology of archaeological sediments: an examination of taphonomic aspects”, Journal of Archaeological Science: Reports, 33, 102522. https://doi.org/10.1016/j.jasrep.2020.102522
SAINZ-ELIPE, Sandra; LATORRE, José M.; ESCOSA, Raul; MASIÀ, Montserrat; FUENTES, Marius V.; MAS-COMA, Santiago; BARGUES, María D. (2010): “Malaria resurgence risk in southern Europe: climate assessment in an historically endemic area of rice fields at the Mediterranean shore of Spain”, Malaria Journal, 9(1), pp. 1–16. https://doi.org/10.1186/1475-2875-9-221
SALLARES, Robert; GOMZI, Susan (2001): “Biomolecular archaeology of malaria”, Ancient Biomolecules, 3(3), pp. 195-213.
SAVAGE-SMITH, Emilie (2013): “Medicine in Medieval Islam”, in D. Lindberg (Ed.), The Cambridge History of Science, pp. 139-167. Cambridge: Cambridge University Press.
SETZER, Teddi J. (2014): “Malaria detection in the field of paleopathology: A Meta-Analysis of the state of the art”, Acta Tropica, 140, pp. 97–104. https://doi.org/10.1016/j.actatropica.2014.08.010
SMITH-GUZMÁN, Nicole E. (2015): “Cribra orbitalia in the ancient Nile Valley and its connection to malaria”, International Journal of Paleopathology, 10, pp. 1–12. https://doi.org/10.1016/j.ijpp.2015.03.001
TAYLOR, Michael; RUTLAND, Paul; MOLLESON, Theya (1997): “A sensitive polymerase chain reaction method for the detection of Plasmodium species DNA in ancient human remains”, Ancient Biomolecules, 1(3), pp. 193-203.
THÉODORIDÈS, Jean (1955): “La Parasitologie et la Zoologie dans l’œuvre d’Avenzoar”, Revue d’histoire des sciences et de leurs applications, 8(2), pp. 137-145.
VÁZQUEZ DE BENITO, María C.; ÁLVAREZ MORALES, Camilo (Eds.) (2003): El Libro de Las Generalidades de La Medicina. Madrid: Trotta.
WALKER, Phillip L.; BATHURST, Rhonda R.; RICHMAN, Rebecca; GJERDRUM, Thor; ANDRUSHKO, Valerie A. (2009): “The causes of porotic hyperostosis and cribra orbitalia: a reappraisal of the iron-deficiency-anemia hypothesis”, American Journal of Physical Anthropology, 139(2), pp. 109–125. https://doi.org/10.1002/AJPA.21031
WEATHERALL, David J. (2008): “Genetic variation and susceptibility to infection: the red cell and malaria”, British Journal of Haematology, 141(3), pp. 276–86. https://doi.org/10.1111/j.1365-2141.2008.07085.x
WEATHERALL, David J.; CLEGG, John B. (2008): The Thalassaemia Syndromes. New Jersey: John Wiley & Sons.
WHARTON, David (1980): “Nematode Egg-Shells”, Parasitology, 81(2), pp. 447–463. https://doi.org/10.1017/S003118200005616X
WIPASA, Jiraprapa.; ELLIOTT, Salenna.; XU, Huji; GOOD, Michael F. (2002): “Immunity to asexual blood stage malaria and vaccine approaches”, Immunology and Cell Biology, 80(5), pp. 401–414. https://doi.org/10.1046/j.1440-1711.2002.01107.x
WORLD HEALTH ORGANIZATION (2025): “World malaria report 2025: addressing the threat of antimalarial drug resistance”, World Health Organization.
ZHAO, Xia; SMITH, David L.; TATEM, Andrew J. (2016): “Exploring the spatiotemporal drivers of malaria elimination in Europe”, Malaria Journal, 15(1), pp. 1–13. https://doi.org/10.1186/s12936-016-1175-z
ZINK, Albert; HAAS, Cristopher; HERBERTH, K.; NERLICH, Andreas (2001): “PCR amplification of Plasmodium DNA in ancient human remains”, Ancient Biomolecules, 3, p. 293.
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